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Drug Reference

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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Antihistamines Combinations with Analgesics Effervescent tablet

Additional titles for this drug

Alka-Seltzer Plus Cold and Cough Effervescent Tablet (Citrus), Alka-Seltzer Plus Flu Effervescent Tablet (Citrus)

What is this medicine?

ACETAMINOPHEN; CHLORPHENIRAMINE; DEXTROMETHORPHAN; PHENYLEPHRINE (a set a MEE noe fen; klor fen IR a meen; dex troe meth OR fan; fen il EF rin) is a combination of a pain reliever, an antihistamine, a cough suppressant, and a decongestant. It is used to treat the aches and pains, cough, fever, congestion, runny nose, and sneezing of a cold. This medicine will not treat an infection.

How should I use this medicine?

This medicine is taken by mouth. Mix this medicine in a 4 ounce glass of water. Follow the directions on the package label. Take your medicine at regular intervals. Do not take it more often than directed.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 12 years old for selected conditions, precautions do apply.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • chest pain, tightness

  • dizziness, nervousness, or sleeplessness

  • fast, irregular heartbeat

  • trouble passing urine or change in the amount of urine

  • unusual bleeding or bruising

  • unusually weak or tired

  • yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • drowsiness

  • dry eyes, mouth

  • loss of appetite

  • stomach upset

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • cocaine

  • ergot alkaloids like dihydroergotamine, ergonovine, ergotamine, methylergonovine

  • MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate

  • stimulant medicines like dextroamphetamine and others

This medicine may also interact with the following medications:

  • alcohol

  • bretylium

  • furazolidone

  • imatinib

  • isoniazid

  • linezolid

  • mecamylamine

  • medicines for anxiety or sleep

  • medicines for blood pressure like atenolol, clonidine, doxazosin, methyldopa, metoprolol

  • medicines for chest pain like isosorbide dinitrate, nitroglycerin

  • medicines for enlarged prostate like tamsulosin

  • medicines for sleep during surgery

  • other medicines for cold, cough or allergy

  • other medicines with acetaminophen

  • procarbazine

  • reserpine

  • St. John's Wort

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Throw away any unused medicine after the expiration date.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • asthma

  • cough that does not go away

  • cough with a lot of phlegm

  • diabetes

  • glaucoma

  • heart disease

  • high blood pressure

  • if you frequently drink alcohol containing drinks

  • liver disease

  • phenylketonuria

  • taken an MAOI like Carbex, Eldepryl, Marplan, Nardil, or Parnate in last 14 days

  • thyroid disease

  • trouble passing urine

  • an unusual or allergic reaction to acetaminophen, chlorpheniramine, dextromethorphan, phenylephrine, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding